Micky van de Ven Brace Ends Everton's Run at Brand New Stadium
Micky van de Ven became the first backline player to score two goals in a Premier League game for Spurs since the Belgian defender in spring 2013.
Match summary
The Spurs defender heads into the net twice in opening period
Everton's Jake O'Brien has goal ruled after video check
Senegalese midfielder nets final goal in dying moments
The defeat is Everton's initial at their new ground
Micky van de Ven scored twice as Spurs prolonged their winning streak in away games in the Premier League and handed the Toffees their initial loss at Hill Dickinson Stadium.
The Toffees were unbeaten in their last five matches at their recently opened stadium at Bramley-Moore Dock, having departed Goodison Park behind after 133 years at the conclusion of the previous campaign.
But Spurs captain the Dutchman struck twice from set-pieces in the opening 45 minutes to place their impressive record at jeopardy, and they were failed to mount a comeback before Pape Matar Sarr - assisted by former Toffees attacker the Brazilian - headed home a final goal to seal the victory.
Jake O'Brien believed he had levelled the tally a short while after Van de Ven's first goal, glancing a powerful header past the Spurs keeper from an set-piece.
The Portuguese striker, in the meantime, failed to convert a number of chances, while Vicario made a succession of fine saves to guarantee the London club went five matches on the road without defeat in the Premier League.
But the video assistant referee stepped in, advising Craig Pawson to review the goal on the screen and the referee decided that the winger and Iliman Ndiaye were in offside positions and had impeded with the Tottenham goalkeeper.
The win elevates Thomas Frank's team into third place in the Premier League, a handful of points off north London rivals and leaders Arsenal.
The Merseyside club remain 14th and are half a dozen points ahead of the drop zone.
Tottenham analysis: The defender excels in role at both ends of pitch
Following a uninspiring midweek display in the European competition against Monaco, where they managed a only two shots on goal, Frank chose the French striker in attack instead of ex-Everton forward the Brazilian.
The summer signing was failed to make much of an impact before being replaced for the substitute after 60 minutes on the field, but it turns out he proved unnecessary in the final outcome.
Defender the Dutchman transformed into an attacking force to be reckoned with.
Spurs' opening strike came from a well-worked set-piece play, with Rodrigo Bentancur directing the ball back across the six-yard box for an free the defender to score.
And the captain - stepping up as skipper in the Argentine's unavailability - added his second in first-half stoppage time as he rose above the England keeper to head home.
The Dutchman was just as impressive in defensive duties, combining well with Kevin Danso as the duo handled excellently with the numerous deliveries sent their way by the opposition.
Everton analysis: Everton missing finishing touch
The club's recent stadium had been a fortress, but it seems the novelty may have faded slightly and fans flocked to the exits after Sarr's third for Tottenham.
The end in the team's winning streak at home will not be a major worry for David Moyes, but their striker situation will be.
Beto and Thierno Barry - the Toffees' two recognised strikers - had netted only one league goal between them before Sunday's match.
And they were failed to add to that poor record on a wet and gloomy night on Merseyside.
The striker's performance was epitomized when he chose to overhead kick a clear chance from close range, even with having room and opportunity to readjust for a simpler shot that would have challenged the keeper.
The substitute, as well, failed to influence the game after replacing the starter in the 65th minute.
It was not for a shortage of chance. Most of the home side's offensive moves came through the winger and the forward, who tirelessly delivered dangerous crosses into the Spurs box.
Upcoming fixtures for these two sides?
The Toffees: The team travel to the Stadium of Light in the top flight on Monday, 3 November at 8 PM.
Spurs: Spurs travel to St James' Park on late October for their fourth-round League Cup match against Newcastle.